A church bus from North Carolina crashed into an SUV and a tractor-trailer after it blew a tire and crossed a median on I-40 in eastern Tennessee on Wednesday, killing at least eight people and injuring, according to police and news outlets.

Six of the 18 bus passengers were killed as well as the big rig driver and one person in the SUV. Fourteen people were injured and four were airlifted from the scene for emergency medical care.