Writer, actor, director Harold Ramis has died at age 69.

Ramis was best known for his roles in "Ghostbusters" and "Stripes," and for writing and directing comedy classics like "Caddyshack" and Groundhog Day."

Ramis had been battling a rare auto-immune disease since 2010, and died from complications early Monday morning in Chicago. He was surrounded by his family. 

He is survived by his wife Erica, his sons Julian and Daniel, his daughter Violet, and two grandchildren.

Ramis got his start in comedy as Playboy Magazine's joke editor and reviewer, according to IMDB.com. 

Ramis' Hollywood debut came when he collaborated on the script of "National Lampoon's Animal House."

In addition to "Caddyshack" and others, the comedy legend directed "National Lampoon's Vacation," "Analyze This" and several other films. He also wrote sequels to his films, including "Ghostbusters 2" and "Caddyshack 2."

PHOTOS: Remebering the work of Harold Ramis 

Learn more about Ramis and his career.